Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 166378
Gene Symbol: SPATA5
SPATA5
0.100 GeneticVariation disease GWASDB Genome-wide association study identifies two novel genomic regions in irritable bowel syndrome. 24797007 2014
Entrez Id: 9863
Gene Symbol: MAGI2
MAGI2
0.300 Biomarker disease GENOMICS_ENGLAND Intestinal epithelial barrier dysfunction in disease and possible therapeutical interventions. 21143118 2011
Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
0.240 Biomarker disease RGD Alterations in colonic corticotropin-releasing factor receptors in the maternally separated rat model of irritable bowel syndrome: differential effects of acute psychological and physical stressors. 20096320 2010
Entrez Id: 1395
Gene Symbol: CRHR2
CRHR2
0.230 Biomarker disease RGD Alterations in colonic corticotropin-releasing factor receptors in the maternally separated rat model of irritable bowel syndrome: differential effects of acute psychological and physical stressors. 20096320 2010
Entrez Id: 3363
Gene Symbol: HTR7
HTR7
0.210 Biomarker disease RGD The aim of this study was to investigate the role of the 5-HT(7) receptor in the pathogenesis of IBS. 18167178 2007
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.210 Biomarker disease RGD Probiotics VSL#3 protect against development of visceral pain in murine model of irritable bowel syndrome. 23691109 2013
Entrez Id: 8517
Gene Symbol: IKBKG
IKBKG
0.200 Therapeutic disease RGD Colon-targeted cell-permeable NFκB inhibitory peptide is orally active against experimental colitis. 22428658 2012
Entrez Id: 2923
Gene Symbol: PDIA3
PDIA3
0.200 Biomarker disease RGD The results of Western blotting confirmed that PDIA3 was indeed over-expressed in colonic mucosa of IBS rat. 20367971 2010
Entrez Id: 2923
Gene Symbol: PDIA3
PDIA3
0.200 ModifyingMutation disease RGD The effect of PDIA3 gene knockout on the mucosal immune function in IBS rats. 26221224 2015
Entrez Id: 3921
Gene Symbol: RPSA
RPSA
0.200 Biomarker disease RGD Proteomic analysis of colonic mucosa in a rat model of irritable bowel syndrome. 20461717 2010
Entrez Id: 51085
Gene Symbol: MLXIPL
MLXIPL
0.210 Biomarker disease MGD
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.100 GeneticVariation disease LHGDN This study investigates the association of psychological symptoms with the distribution of two serotonin transporter gene (SERT) polymorphisms, located in the promoter region (5-HTTLPR) and in intron 2 (STin2 VNTR), in patients with irritable bowel syndrome (IBS). 17909168 2007
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.100 Biomarker disease LHGDN Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome. 15188158 2004
Entrez Id: 3359
Gene Symbol: HTR3A
HTR3A
0.070 Biomarker disease LHGDN Do polymorphisms in the human 5-HT3 genes contribute to pathological phenotypes? 17052218 2006
Entrez Id: 3359
Gene Symbol: HTR3A
HTR3A
0.070 Biomarker disease LHGDN First evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor-type 3E gene with diarrhea predominant irritable bowel syndrome. 18614545 2008
Entrez Id: 2641
Gene Symbol: GCG
GCG
0.070 Biomarker disease LHGDN GLP-1 suppresses gastrointestinal motility and inhibits the migrating motor complex in healthy subjects and patients with irritable bowel syndrome. 18298441 2008
Entrez Id: 6331
Gene Symbol: SCN5A
SCN5A
0.040 GeneticVariation disease LHGDN Therefore, our aims were to evaluate SCN5A as a candidate gene involved in the pathogenesis of IBS and to determine physiological consequences of identified mutations. 19056759 2009
Entrez Id: 3357
Gene Symbol: HTR2B
HTR2B
0.010 Biomarker disease LHGDN The aim of the present study was to investigate the distribution and function of 5-HT(2B) receptors in human colon, and to establish their possible role in the aetiology of IBS.2. 11877320 2002
Entrez Id: 285242
Gene Symbol: HTR3E
HTR3E
0.010 Biomarker disease LHGDN The novel HTR3E 3'-UTR variant c.*76G>A (rs62625044) was associated with female IBS-D (P = 0.033, OR = 8.53). 18614545 2008
Entrez Id: 574515
Gene Symbol: MIR510
MIR510
0.010 Biomarker disease LHGDN First evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor-type 3E gene with diarrhea predominant irritable bowel syndrome. 18614545 2008
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.010 AlteredExpression disease LHGDN These results suggest that the serum levels of MBL and the occurrence of SA in women with CD and IBS are not causally related. 18478332 2008
Entrez Id: 166378
Gene Symbol: SPATA5
SPATA5
0.100 GeneticVariation disease GWASCAT Genome-wide association study identifies two novel genomic regions in irritable bowel syndrome. 24797007 2014
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 Biomarker disease CTD_human Rapid development of colitis in NSAID-treated IL-10-deficient mice. 12404228 2002
Entrez Id: 7177
Gene Symbol: TPSAB1
TPSAB1
0.310 Biomarker disease CTD_human Thus, our findings link duplications in TPSAB1 with irritable bowel syndrome, cutaneous complaints, connective tissue abnormalities, and dysautonomia. 27749843 2016
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 Biomarker disease BEFREE Production of IL10 in response to bacterial motifs was normal in all IBD patients. 21519361 2011